Rahim et al. show that immune checkpoint blockade activates CD8 T cell differentiation and proliferation in the lymph node, not within the tumor microenvironment, and these cells can be detected in transit via blood profiling.
Frontiers Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes - ScienceDirect
Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors
Cancers, Free Full-Text
Enhanced Primary Tumor Penetration Facilitates Nanoparticle Draining into Lymph Nodes after Systemic Injection for Tumor Metastasis Inhibition
Frontiers Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?
// Powered by Mass Cytometry - Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist
// Powered by Mass Cytometry - Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Stem-like exhausted and memory CD8+ T cells in cancer
Quality of CD8+ T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context
PDF) A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity
CD8+ T cell differentiation and dysfunction in cancer
Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment - Gong - Advanced NanoBiomed Research - Wiley Online Library