Laser speckle contrast imaging (LSCI) is a powerful visualization tool for quantifying blood flow in tissues, providing simplicity of configuration, ease of use, and intuitive results. With recent advancements, smartphone and camera technologies are suitable for the development of smartphone-based LSCI applications for point-of-care (POC) diagnosis. A smartphone-based portable LSCI endoscope system was validated for POC diagnosis of vascular disorders. The endoscope consisted of compact LED and laser illumination, imaging optics, and a flexible fiberscope assembled in a 3D-printed hand-held cartridge for access to body cavities and organs. A smartphone’s rear camera was mounted thereto, enabling endoscopy, LSCI image acquisition, and processing. Blood flow imaging was calibrated in a perfused tissue phantom consisting of a microparticle solution pumped at known rates through tissue-mimicking gel and validated in a live rat model of BBN-induced bladder cancer. Raw LSCI images successfully visualized phantom flow: speckle flow index showed linearity with the pump flow rate. In the rat model, healthy and cancerous bladders were distinguishable in structure and vasculature. The smartphone-based low-cost portable mobile endoscope for monitoring blood flow and perfusion shows promise for preclinical applications and may be suitable for primary diagnosis at home or as a cost-effective POC testing assay.
A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses - Narita - 2021 - Advanced Materials - Wiley Online Library
Cell-Free Biosensors: Synthetic Biology Without Borders
Recent advances in graphene-based biosensor technology with applications in life sciences, Journal of Nanobiotechnology
Different label-free optical biosensor based on evanescent wave. (A)
Frontiers Progress on Structured Biosensors for Monitoring Aflatoxin B1 From Biofilms: A Review
Universal Biosensors Full Year 2022 Earnings: Misses Expectations
Textile-embedded cell-free biosensors
Label-free optical biosensors in the pandemic era
Applications of Cutting-Edge Biosensors in Healthcare and Biomedical Research
Cell-free biosensors for biomedical applications - ScienceDirect
Song Of Memories Complete Scenario Igg - Colaboratory
DNA-based label-free electrochemical biosensors: From principles to applications - ScienceDirect
Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic